2. Signaling Pathways
  3. GPCR/G Protein
  4. Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor (NPR)

Natriuretic Peptide Receptor; NPR; NPR-A; NPR-B; NPR-C

Natriuretic peptide receptors can be divided into three types: NPR-A, NPR-B (guanylate cyclase-A and guanylate cyclase-B) and NPR-C. All three receptors have an effect on biological second messengers. NPR-A and NPR-B are guanylate cyclase receptors, and their activation can lead to increased cGMP levels, while the activation of NPR-C can lead to the inhibition of adenylate cyclase activity and increased phospholipase C activity. Natriuretic peptide receptors play an important role in the regulation of blood pressure and cardiovascular homeostasis[1].

Natriuretic Peptide Receptor (NPR) Related Products (28):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0003
    Nesiritide
    		Agonist 99.75%
    Nesiritide (Brain Natriuretic Peptide-32 human) is a recombinant human B-type natriuretic peptide. Nesiritide is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide shows vasodilatory, diuretic, and natriuretic activities. Nesiritide is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury.
    Nesiritide
  • HY-113283
    Homogentisic acid
    		Activator 99.68%
    Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer.
    Homogentisic acid
  • HY-P1419
    AP 811
    		Antagonist 99.64%
    AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.
    AP 811
  • HY-P2469
    Brain Natriuretic Peptide-45, mouse
    		98.02%
    Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities.
    Brain Natriuretic Peptide-45, mouse
  • HY-P2026
    A 71915
    		Antagonist 99.28%
    A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
    A 71915
  • HY-P11675
    Rolzavosoritide
    Rolzavosoritide is a C-type natriuretic peptide.
    Rolzavosoritide
  • HY-P990951
    Vixticibart
    		Agonist
    Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension.
    Vixticibart
  • HY-153650
    JS11
    		Inhibitor 99.22%
    JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models.
    JS11
  • HY-P1526
    ANP [Des18-22] 4-23 amide (rat)
    		Ligand 99.16%
    ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C.
    ANP [Des18-22] 4-23 amide (rat)
  • HY-122610
    VUT-MK142
    		Activator 99.57%
    VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.
    VUT-MK142
  • HY-P10279
    Anaritide
    		98.83%
    Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival.
    Anaritide
  • HY-P10869
    dCNP
    		Activator
    dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses.
    dCNP
  • HY-P990921
    Imelciment
    HY-P990921 is an NPR1-targeting half-IG G4 -κ/h-CH2-CH3 type human antibody.
    Imelciment
  • HY-P10259
    BNP(1-32), porcine
    BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation.
    BNP(1-32), porcine
  • HY-P1573A
    Brain Natriuretic Peptide-45, rat TFA
    Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.
    Brain Natriuretic Peptide-45, rat TFA
  • HY-177062
    NPRA agonist-11
    		Agonist
    NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist, with AC50 values of 1.681 μM and 0.989 μM for humans and monkeys, respectively. NPRA agonist-11 can be used in the research of cardiovascular diseases and other disorders.
    NPRA agonist-11
  • HY-P2687
    Ularitide
    Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
    Ularitide
  • HY-120521
    Urodilatin
    		Activator
    Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
    Urodilatin
  • HY-P3758
    BNP (1-21), Pro (Human)
    		Activator
    BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life.
    BNP (1-21), Pro (Human)
  • HY-P0003A
    Nesiritide acetate
    		Agonist
    Nesiritide (Brain Natriuretic Peptide-32 human) acetate is a recombinant human B-type natriuretic peptide. Nesiritide acetate is a NPRs agonist, with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate regulates V1/2 activation/inactivation of the L-type calcium channel. Nesiritide acetate shows vasodilatory, diuretic, and natriuretic activities. Nesiritide acetate is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury.
    Nesiritide acetate